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De aktive stoffer buprenorphin og nalbuphin er midler der virker som de andre syntetiske opioider, Gentlemen de har desuden en modsatrettet virkning, idet de også spærrer for andre opioiders virkning.Hvis du absolut har behov for smertelindring eller febernedsættende medicin, er paracetamol i lavest mulige dosis i kortest mulig tid en mulighed,